Immunologist to the Regency

For most of his life, he tirelessly fought against the smallpox, a highly contagious disease with a fearsome mortality rate. But Dr. Edward Jenner (1749 – 1823) had to wait until late in life to finally get some recognition.

That’s when he became the celebrated Immunologist to the Regency.

To put Dr. Jenner’s celebrity in perspective, it bears examining how things used to be. It wasn’t just the mortality rate of smallpox that was so bad. Those who survived the disease were often scarred, maimed or blinded.

Mary Dudley, Lady Sidney caught the pox while attending to a very ill Elizabeth I. Her husband was much aggrieved. “..I found her as fowle a ladie as the smale pox could make her..”

You get a sense of how appalling its ravages were from the lines of a sonnet, written in tribute to Dr. Jenner:

“In village paths, hence, may we never find
their youth on crutches, their children blind;
Nor, when the milk-maid, early from her bed,
beneath the may-bush that embowr’s her head,
sings like a bird, e’er grieve to meet again
The fair cheek injur’d by the scars of pain..”
Good tidings, or, News from the farm, a Poem by Robert Bloomfield (1805)

The practice of inoculating against smallpox had been around for some time but it was quite a risky procedure and not always reliable. Indeed, the treatment was often worse than the cure. Fingers must have been crossed when young Edward Jenner received his own inoculation.

Thank God it didn’t kill him.

As a practicing physician, Dr. Jenner was an keen observer of nature and not afraid to try out ideas. Using scientific experiments, he perfected the work of others to promulgate safe and effective vaccination.

Dr. Jenner’s vocation for zoology led him to discover how the cuckoo chick uses its back to push his rivals’ eggs out of the nest.
Photo By Anderson, et al – CC BY 4.0 Wikimedia

It took awhile for his alternative immunization technique to catch on. Understandably, patients resisted the notion of accepting diseased material from an animal (the cowpox virus) into their bodies. A lay person might view such a procedure in the same way as being bitten by a rabid dog.

Dr. Jenner had to work pretty hard to get folks to trust him.

Trust me, I’m a doctor.

Objections to this newfangled procedure abounded. No less a physician than the Surgeon Extraordinary to the Prince of Wales voiced his concern. Dr. John Birch’s efforts to discredit vaccination bear a strong resemblance to the ones today.

Check out Vaxopedia.org for a great run-down on this.

It must have caused the royal physician no end of chagrin when the Prince Regent, along with his royal brothers of York and Clarence, voiced their support for the Jennerian practice of inoculation:

“His Royal Highness was pleased.. to declare his admiration of this invaluable discovery; to patronize and to cherish it in every way; and at the same time, to announce the highest esteem for the worth and character for its author.”
The life of Edward Jenner, MD, etc., physician extraordinary to the King..with illustrations of his doctrines, and selections from his correspondence, Vol I
by John Baron (1827)

Dr. Jenner rode on a wave of celebrity, fêted by Regency society. Admired to such a degree, many important persons sought his advice and assistance in ways that had nothing to do with getting a shot.

For instance, it was well known that the man behind the vaccine was held in high esteem on the Continent. In 1803, The Marquess of Hertford’s son, young Lord Yarmouth, managed to get himself detained in Paris after hostilities between France and England resumed. Dr. Jenner, upon the marquess’ request, interceded with the French.  Lord Yarmouth was released, going on to a rather dubious career of “undisguised debauchery,” as described in diarist Charles Greville’s scandalous memoirs of the times.

When Thackeray’s Vanity Fair came out, Lord Yarmouth threatened to sue for libel. It seemed the nasty character of Lord Steyne bore a remarkable resemblance to his lordship. — print from the National Portrait Gallery

But fame can be a double-edged sword.

Dr. Jenner’s voluminous correspondence shows how weary he became during the latter part of his life, patiently answering questions and soothing fears expressed in letters from all over the world. He attended to them all, endlessly providing vaccine of his own making, and instruction on how to properly administer it.

Inevitably, there were some failures out of the thousands he immunized.

The most famous case concerned one of Lord Grosvenor’s sons. All the children had been vaccinated years before, yet Master Robert came down with a violent case of the smallpox. Attended by Sir Henry Halford, prominent physician of the ton, the boy survived. It was an event that shocked the ton, delivering a blow to Dr. Jenner’s reputation.

In a letter to one Miss Calcraft* he laments:

“And now this single solitary instance has occurred, all my past labours are forgotten, and I am held up by many, perhaps the majority of the higher classes, as an object of derision and contempt.”
The life of Edward Jenner, MD, etc., physician extraordinary to the King..with illustrations of his doctrines, and selections from his correspondence, Vol II
by John Baron (1827)

Escaping the tumult of fame, Dr. Jenner returned to his medical practice in rural Berkeley, Gloucestershire. From his residence in Chantry Cottage, he treated and vaccinated poor families in a little hut that served as his clinic.

Apart from his correspondence, his meditations and poems show a humble, yet perceptive preoccupation with the natural world, and with the human body. He continued searching for answers, goaded by insatiable curiosity, entreating us all to carry on.

“If we fear all things that are possible, we live without any bounds to our misery.”
— Edward Jenner

 

*Presumably Mary Elizabeth Calcraft, daughter of John Calcraft, MP for Rempston.

 

 

 

Holland House – A Rival to Lansdowne House (part one)

Its turrets and gables lacked the elegance of London’s newer, Palladian town homes.  Its “relics and curios” were dusty books and historic English papers.  Its location was staid Kensington, not fashionable Mayfair.  Its mistress was not even received at court.  But this Regency seat of influence was nontheless a formidable rival to glittering Lansdowne House:

Holland House

Yet great things were done at Holland House–reforms planned and accomplished, literary lions fed with appreciation and encouragement.  All the great names of that period may be found on the lists of the Holland House entertainments.

—  Charles Dickens, “Holland House,” All the Year Round, A Weekly Journal, Vol. 66, 1890

With the Regency barely on the horizon, the house was known as Cope Castle and practically a ruin when it came into the possession of Lord Henry Richard Fox, third Baron Holland.  He was a mere baby and presumably not ready to take on any renovations even though the house had an illustrious history.  Its best days, it seemed, were behind it.

Those days began when Queen Elizabeth I granted a part of Kensington Manor to one Walter Cope–that part that once belonged to the Abbot of Abingdon–and built a multi-turreted Jacobean mansion that others mockingly called Cope’s Castle.  The Renaissance had penetrated English architecture by the time of its construction in 1607 but classical features like columns, arcades, parapets and the like were applied in a more freeform style rather than with any strict order that characterized the later Palladian movement.  Cope Castle, unlike Lansdowne House, was more like a free spirit.

the haunted Gilt Room

Cope’s daughter inherited the house and it became greatly enlarged upon her union with the Rich family, also grown wealthy on confiscated church property when its patriarch had prosecuted Sir Thomas More on Henry VIII’s behalf.  Her husband was Henry Rich, Earl of Holland, from whom the house takes its present name.   He negotiated the marriage of Henrietta Maria to Charles I and built the house’s famous gilt-room in expectation of entertaining the new Queen there.  This did not come to pass, nor was the Earl to survive the coming storm.  His ghost was said to be seen in that very room, richly dressed as he had been on the scaffold, holding his head in his hands.

After the Restoration of Charles II, the house was sold to Henry Fox, whose sire had the distinction of fathering this first of three sons at the age of seventy-three.  Fox eloped with one of the famous Lennox sisters and it was his grandson, also named Henry, third Baron Holland, who made Holland House a rival in Regency gatherings, as we shall soon see.  Today, Holland House is a ruin, destroyed by a fire-bomb in World War II.

Holland House library – World War II